MCI refers to mild cognitive impairment, an early stage of measurable cognitive decline that is greater than expected for age but does not yet significantly impair independent daily function. It is an at-risk state for dementia progression in some individuals.
New research demonstrates that blood tests measuring p-tau217 protein can identify dementia risk up to 25 years before symptoms and significantly improve diagnostic accuracy in clinical practice.
Blood-based biomarkers including brain-derived tau and amyloid-beta are enabling earlier Alzheimer's disease diagnosis through non-invasive testing, though confirmatory imaging remains necessary before treatment initiation.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07580703 |
A Phase I Study of [18F]Flortaucipir PET Imaging in Chinese Subjects: Safety, Pharmacokinetics, Biodistribution, Radiation Dosimetry, and Preliminary Diagnostic Efficacy |
RECRUITING | PHASE1 |
| NCT07553117 |
Accexible Speech Analysis for MCI Detection and Monitoring in Colombia |
COMPLETED | |
| NCT07512193 |
Personalized Closed-Loop Brain Stimulation for Patients With Mild Cognitive Impairment |
NOT_YET_RECRUITING | NA |
| NCT07417891 |
Ketogenic Diet to Reduce Osteoarthritis Pain in MCI |
NOT_YET_RECRUITING | NA |
| NCT07366346 |
Telehealth-Adapted Compensatory Training and Intervention for Cognition |
NOT_YET_RECRUITING | NA |
| NCT07297121 |
Validation of the Montreal Cognitive Assessment (MoCA) Version 8.x and MoCA-MIS in Greece. |
NOT_YET_RECRUITING | |
| NCT07272811 |
Neurocognitive Assessment Platform 4 Alzheimer |
RECRUITING | |
| NCT07244770 |
The Effects of Some Antihyperglycemic Drugs on Cognitive Function and Risk of Depression of Diabetic Patients |
RECRUITING | |
| NCT07235111 |
Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases |
RECRUITING | |
| NCT07160582 |
Cognitive-Motor Training for AD/ADRD Prevention |
NOT_YET_RECRUITING | NA |
