MCI refers to mild cognitive impairment, an early stage of measurable cognitive decline that is greater than expected for age but does not yet significantly impair independent daily function. It is an at-risk state for dementia progression in some individuals.
A Cochrane review of 17 trials finds amyloid-beta-targeted monoclonal antibodies offer negligible benefit in MCI or mild Alzheimer’s. In a phase 3 trial, the oral agent valiltramiprosate (ALZ-801) showed significant cognitive and functional improvements in the MCI subgroup, with no brain swelling risk. The company plans another phase 3 study in 2026.
New research demonstrates that blood tests measuring p-tau217 protein can identify dementia risk up to 25 years before symptoms and significantly improve diagnostic accuracy in clinical practice.
Blood-based biomarkers including brain-derived tau and amyloid-beta are enabling earlier Alzheimer's disease diagnosis through non-invasive testing, though confirmatory imaging remains necessary before treatment initiation.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07766993 |
Developing and Testing an AI-Based Cognitive Intervention Program |
NOT_YET_RECRUITING | NA |
| NCT07731334 |
Prevalence of Mild Cognitive Impairment and Dementia in Patients Admitted to Non-neurological Rehabilitation Wards |
RECRUITING | NA |
| NCT07688382 |
The Effect of Lavender Aromatherapy on Cognitive Function in Older Adults With Mild Cognitive Impairment |
NOT_YET_RECRUITING | NA |
| NCT07630688 |
Validation and Reliability of the Turkish Version of the Montreal Cognitive Assessment-Basic (MoCA-B) in Individuals With Low Educational Level |
COMPLETED | |
| NCT07612800 |
Tailored Brain Health Insights Through Nurturing Knowledge-based Change - Stakeholder-driven, Human-centered, AI-powered Refinement for Prevention |
NOT_YET_RECRUITING | NA |
| NCT07580703 |
A Phase I Study of [18F]Flortaucipir PET Imaging in Chinese Subjects: Safety, Pharmacokinetics, Biodistribution, Radiation Dosimetry, and Preliminary Diagnostic Efficacy |
RECRUITING | PHASE1 |
| NCT07553117 |
Accexible Speech Analysis for MCI Detection and Monitoring in Colombia |
COMPLETED | |
| NCT07512193 |
Personalized Closed-Loop Brain Stimulation for Patients With Mild Cognitive Impairment |
NOT_YET_RECRUITING | NA |
| NCT07417891 |
Ketogenic Diet to Reduce Osteoarthritis Pain in MCI |
NOT_YET_RECRUITING | NA |
| NCT07366346 |
Telehealth-Adapted Compensatory Training and Intervention for Cognition |
RECRUITING | NA |
