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Understanding Mechanisms of Synaptic Degeneration Underlying Clinical Symptoms in Patients With MDs and NDs.

NCT07234851 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2025-12-11

No results posted yet for this study

Summary

Clinical Study A. Retrospective Neuropathological Study of Synapse dysfunction.

This is a cross-sectional study of patients retrospectively collected from existing postmortem collections and from existing collections of iPSC-derived neurons. Postmortem tissue and iPSC-derived neurons from age and sex-matched unaffected volunteers without a MD or ND diagnosis are used as controls.

Conditions

  • Schizophrenia Disorder
  • Frontotemporal Dementia, Behavioral Variant
  • Major Depressive Disorder (MDD)
  • Bipolar Disorder (BD)
  • Alzheimer's Disease

Sponsors & Collaborators

  • University of Eastern Finland

    collaborator OTHER

  • University of the Basque Country (UPV/EHU)

    collaborator OTHER

  • Natural and Medical Sciences Institute (NMI)

    collaborator UNKNOWN

  • Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

    lead OTHER

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-01
Primary Completion
2029-06-30
Completion
2029-09-30

Countries

  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07234851 on ClinicalTrials.gov