Symptom Based Treatment Affects Brain Plasticity - Cognitive Training in Patients With Affective Symptoms

Summary

The aim of the study is the examination of brain plasticity on on affective symptoms after neuromodulation with fMRI (functional magnetic resonance imaging) neurofeedback. During the fMRI neurofeedback training, patients with depression as well as patients with schizophrenia are trained to consciously regulate the activity of areas which are associated with the cognitive reappraisal of emotional stimuli.The aim is to improve the patients' subjective emotional processing and perception in everyday life as well as to investigate the impact of neurofeedback on resting-state networks in the brain. Healthy participants will be investigated as control group.

Conditions

• Depression
• Schizophrenia

Interventions

PROCEDURE

fMRI

collection of functional brain data for 1 hour per day

BEHAVIORAL

Neurofeedback

Task of the participants is to increase the activity in the selected brain region (left or right prefrontal cortex). After regulation they will get a feedback about the regulation success. (Patients: days 3 \& 4; controls: Days 2 \& 3)

OTHER

PANAS

to assess the mood before and after the fMRI and after 4 weeks during a telephone interview

OTHER

BDI-II

to assess depressive symptomatology before neurofeedback and 4 weeks after the intervention during telephone interview

OTHER

ERQ

To assess emotion regulation strategies before and after neurofeedback training (patients: day 3\&4; controls: day 2\&3) and after 4 weeks during a telephone interview

Sponsors & Collaborators

• RWTH Aachen University

  lead OTHER

Principal Investigators

• Klaus Mathiak, Prof MD PhD · University Hospital RWTH Aachen, Department of Psychiatry, Psychotherapy and Psychosomatics

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-08-29

Primary Completion

2019-12-06

Completion

2019-12-06

Countries

• Germany

Study Locations