MedTrace Logo

Transcriptomic Profiling of Cumulus Cells From CAPA-IVM

NCT07197255 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2025-11-21

No results posted yet for this study

Summary

Capacitation in vitro maturation (CAPA-IVM) has improved oocyte maturation and resulted in live births. Because cumulus cells (CCs) communicate bidirectionally with the oocyte, their transcriptomic profile may serve as a non-invasive biomarker of oocyte and embryo competence. This prospective pilot study will analyze CCs gene expression after CAPA-IVM using RNA sequencing and pathway analysis, and correlate findings with embryological outcomes including fertilization, day-3 cleavage, and blastocyst formation. Results are expected to provide insights into the molecular basis of oocyte competence and support development of non-invasive embryo selection strategies.

Conditions

  • PCOS (Polycystic Ovary Syndrome)
  • Cumulus Cell
  • Capacitation IVM
  • Transcriptomic Profiling

Sponsors & Collaborators

  • Vrije Universiteit Brussel

    collaborator OTHER

  • Mỹ Đức Hospital

    lead OTHER

Principal Investigators

  • Lan N Vương, PhD, MD · University of Medicine and Pharmacy at Ho Chi Minh City

Eligibility

Min Age
18 Years
Max Age
38 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-16
Primary Completion
2026-01-30
Completion
2026-03-30

Countries

  • Vietnam

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07197255 on ClinicalTrials.gov