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Compromised Microcirculation in Women With Polycystic Ovary Syndrome

NCT00757185 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 28

Last updated 2016-07-04

No results posted yet for this study

Summary

The scientific aims of the study are to determine how peripheral microcirculatory responsiveness is altered in obese women with Polycystic Ovary Syndrome (PCOS) during local heating and to determine the mechanism for testosterone effects on peripheral microcirculatory responsiveness in women with PCOS.

Conditions

  • Polycystic Ovary Syndrome

Interventions

DRUG

ganirelix acetate

GnRH antagonist, subcutaneous injection, 0.25 mg/day for 21 days

DRUG

methyl testosterone

testosterone, oral administration, day 5 of GnRH administration, 2.5 mg/day

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Yale University

    lead OTHER

Principal Investigators

  • Nina Stachenfeld, PhD · John B. Pierce Laboratory

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-02-29
Primary Completion
2012-04-30
Completion
2012-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00757185 on ClinicalTrials.gov