MedTrace Logo

IVF Outcome in Polycystic Ovary Syndrome Patients

NCT04104958 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2020-01-10

No results posted yet for this study

Summary

1. To investigate the circulating concentrations of phoenixin and their associations with BMI, the concentrations of sex hormones including (LH), (FSH), (E2), (P4), (TT) and steroid hormones enzyme in PCOS patients.
2. To detect the expression PNX and humanin in women with or without PCOS and to elucidate possible correlations with ovarian reserve and clinical outcomes after IVF-ICSI.
3. To investigate relationship between PNX, humanin expression and PI3K/AKT/mTOR and autophagy pathway as a major signaling mechanism in PCOS for targeting new prognostic and therapeutic markers.
4. The study investigates the correlation between oocyte maturity, fertilization, recent biomarkers and a variety of hormonal parameters in follicular fluid.

Conditions

  • Polycystic Ovary Syndrome

Interventions

GENETIC

qRTPCR (mRNA level).

RNA extraction and RT-qPCR Protein extraction and western blotting ELISA assay

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Principal Investigators

  • Madiha Mahros Zakhary farag, Professor · Faculty of medicin Assiut University

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-03-01
Primary Completion
2020-12-01
Completion
2021-02-15

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04104958 on ClinicalTrials.gov