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The Effect of Chlorhexidine Mouthwash on Postprandial Glucose Response in Healthy Individuals

NCT07172009 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2025-09-19

No results posted yet for this study

Summary

The digestion of carbohydrates begins in the mouth through the salivary enzyme amylase which breaks food starches into maltose and disaccharides. The mouth also has a large community of microorganisms which include bacteria, fungi, viruses and protozoa that can also assist in the digestion of carbohydrates. Mouthwashes containing antibacterial compounds such as chlorhexidine are used to kill oral bacteria, but current evidence indicates that a majority of these bacteria are essential for human health.

The aim of this study is to investigate whether chlorhexidine mouthwash can also affect the digestion of carbohydrates. At least 25 individuals will be recruited. Participants will visit the laboratory in two occasions. A saliva and blood sample (fingertip to measure blood glucose) will be taken at baseline. Then, using a randomized, cross-over and double-blind design, the participants will rinse their mouth for two minutes with a placebo or chlorhexidine mouthwash. Then, participants will eat 50 g of white bread and blood glucose will be measured (fingertips) every 30 min for the following 2 hours. Another saliva sample will be collected at the end of each test.

Conditions

  • Glucose Metabolism Disorders (Including Diabetes Mellitus)

Interventions

OTHER

Chlorhexidine mouthwash

Rinsing the mouth with chlorhexidine mouthwash for 2 minutes before consuming 50 g of carbohydrates

OTHER

Placebo mouthwash

Rinsing the mouth with placebo mouthwash for 2 minutes before consuming 50 g of carbohydrates

Sponsors & Collaborators

  • University of Plymouth

    lead OTHER

Principal Investigators

  • Raul Bescos Garcia · University of Plymouth

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-06-08
Primary Completion
2025-12-10
Completion
2026-06-01

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07172009 on ClinicalTrials.gov