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Xylitol Chewing-gums: Concentration in Saliva and Antibacterial Effect

NCT03971981 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2019-06-03

No results posted yet for this study

Summary

a double-blind cross-over in vivo study was performed to measure the salivary concentration of Xylitol released from the two chewing gums containing different amount of the polyol. The study had a cross-over design: the first half of the sample used the chewing-gum with Xylitol as the only sweeteners (64.5% of chewing-gum weight) and the other half use the chewing-gum with Xylitol among the sweeteners (22% of chewing-gum weight), after a 7-days wash-out period, the two sub-groups inverted the chewing gums. Subjects were instructed to consume the products as they normally would be consumed.

Conditions

  • Dental Caries
  • Periodontal Diseases

Interventions

DIETARY_SUPPLEMENT

100% Xylitol Gum

Subjects were instructed to consume the gums as they normally would be consumed.

DIETARY_SUPPLEMENT

22% Xylitol Gum

Subjects were instructed to consume the gums as they normally would be consumed.

Sponsors & Collaborators

  • University of Milan

    collaborator OTHER

  • Università degli Studi di Sassari

    lead OTHER

Principal Investigators

  • Guglielmo Campus · Università degli Studi di Sassari

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
19 Years
Max Age
26 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-02-01
Primary Completion
2018-05-31
Completion
2019-05-28

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03971981 on ClinicalTrials.gov