MedTrace Logo

Efficacy of Different Chlorhexidine Concentrations

NCT02911766 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 59

Last updated 2016-10-05

No results posted yet for this study

Summary

Chlorhexidine is the gold standard of dental plaque prevention, but which concentration is the most effective is not known. The aim of the present study was to compare the plaque and gingivitis inhibiting effect of commercial products containing 0.2%, 0.12% and 0.06% chlorhexidine in a modified experimental gingivitis model.

In three groups of healthy volunteers, experimental gingivitis was induced and monitored over 21days, simultaneously treated with the commercial solutions containing 0.2%, 0.12% and 0.06% chlorhexidine. The maxillary right quadrant of each individual received mouthwash only, whereas the maxillary left quadrant was subject to both rinsing and mechanical oral hygiene. Compliance and side effects were monitored at days 7, 14, and 21. Plaque and gingivitis scores were obtained at baseline and day 21.

The commercial mouthwash containing 0.2% chlorhexidine resulted in statistically significantly lower plaque scores than the 0.12 and 0.06% mouthwashes after 21 days use, whereas no statistically significant difference was found between the effect of the two latter mouthrinses.

A commercial available mouthwash containing 0.2% chlorhexidine proved statistically significant better effect in preventing dental plaque than 0.12% and 0.06% solutions.

Conditions

  • Dental Plaque
  • Gingivitis

Interventions

DRUG

Chlorhexidine 0.2% Mouthrinse

Intervention; Rinsing 60 sec with Comparator solution twice daily for 21 days

DRUG

Chlorhexidine 0.12% mouthrinse

Intervention; Rinsing 60 sec with Comparator solution twice daily for 21 days

DRUG

Chlorhexidine 0.06% mouthrinse

Intervention; Rinsing 60 sec with Comparator solution twice daily for 21 days

Sponsors & Collaborators

  • University of Oslo

    lead OTHER

Principal Investigators

  • Hans R Preus, PhD · Department of periodontics, Dental Faculty, UiO

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
42 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-11-30
Primary Completion
2016-11-30
Completion
2016-12-31

Countries

  • Norway

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02911766 on ClinicalTrials.gov