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AKI After Pulmonary Endarterectomy

NCT07132619 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2026-06-10

No results posted yet for this study

Summary

This retrospective, single-centre observational study evaluates perioperative determinants and clinical outcomes of postoperative acute kidney injury (AKI) in patients undergoing pulmonary endarterectomy (PEA) between 2018 and 2020. AKI is classified according to KDIGO 2012 criteria using both serum creatinine changes and urine output over 48 hours. Preoperative, intraoperative and postoperative variables are assessed using multivariable logistic regression. Intraoperative time variables - including extracorporeal circulation (ECC) duration, deep hypothermic circulatory arrest (DHCA) duration and aortic cross-clamp time - are entered simultaneously to identify which component independently captures renal risk. The study also evaluates a parsimonious multivariable risk-stratification model based on routinely available perioperative data. Secondary outcomes include 30-day mortality, intensive care unit stay, hospital length of stay and renal replacement therapy requirement. Findings from this study may provide insights into perioperative risk stratification and renal monitoring strategies in patients undergoing pulmonary endarterectomy.

Conditions

  • Acute Kidney Injury
  • Acute Kidney Failure
  • Pulmonary Thromboembolisms
  • Hypothermic Circulatory Arrest Time

Sponsors & Collaborators

  • Ebru Girgin Dinc

    lead OTHER

Principal Investigators

  • Atakan ERKILINC, MD, Associate Professor · University of Health Sciences, Kosuyolu Heart Training and Research Hospital, Kartal, ISTANBUL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-06-30
Primary Completion
2025-06-30
Completion
2025-08-01

Countries

  • Turkey (Türkiye)

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07132619 on ClinicalTrials.gov