A Prediction Model in Pregnant Women With Aplastic Anemia

Summary

Aplastic anemia (AA) is a rare haematologic disorder characterized by bone marrow failure and pancytopenia. Its occurrence during pregnancy is exceedingly rare but poses significant risks, including maternal hemorrhage, infections, and perinatal complications such as preterm birth and fetal growth restriction. Consequently, pregnancy with AA is highly perilous for both mothers and infants. Early management is critical to ensure the health of both the mother and the baby. However, there are currently no predictive tools available to assess adverse outcomes in pregnant women with AA. Our center plans to conduct a multicenter, combined retrospective and prospective cohort study.

Conditions

• Aplastic Anemia
• Pregnancy
• Prediction Model

Interventions

OTHER

A combined retrospective and prospective observational follow-up

A combined retrospective and prospective observational follow-up

Sponsors & Collaborators

• Tianjin Medical University General Hospital

  collaborator OTHER

• Lanzhou University Second Hospital

  collaborator OTHER

• The Affiliated Hospital of Inner Mongolia Medical University

  collaborator OTHER

• General Hospital of Ningxia Medical University

  collaborator OTHER

• Peking Union Medical College Hospital

  collaborator OTHER

• Peking University Third Hospital

  collaborator OTHER

• The First Affiliated Hospital of Anhui Medical University

  collaborator OTHER

• Wuhan TongJi Hospital

  collaborator OTHER

• Peking University First Hospital

  collaborator OTHER

• Chinese PLA General Hospital

  collaborator OTHER

• Second Xiangya Hospital of Central South University

  collaborator OTHER

• The First Affiliated Hospital of Soochow University

  collaborator OTHER

• Qilu Hospital of Shandong University

  collaborator OTHER

• Shanxi Provincial People's Hospital

  collaborator OTHER_GOV

• The First Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Shandong Provincial Hospital

  collaborator OTHER_GOV

• Shanxi Bethune Hospital

  collaborator OTHER

• Yantai Yuhuangding Hospital

  collaborator OTHER

• First Affiliated Hospital of Harbin Medical University

  collaborator OTHER

• The Third Affiliated Hospital of Guangzhou Medical University

  collaborator OTHER

• First Affiliated Hospital of Zhejiang University

  collaborator OTHER

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

  collaborator OTHER

• Peking University People's Hospital

  lead OTHER

Principal Investigators

• Xiaohui Zhang, MD · Peking University People's Hospital

Eligibility

Min Age

20 Years

Max Age

50 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-11-27

Primary Completion

2030-06-30

Completion

2030-12-31

Countries

• China

Study Locations