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Foetal Exposure and Epidemiological Transition: Role of Anaemia in Early Life for Non-communicable Diseases Later

NCT02191683 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1748

Last updated 2019-09-30

No results posted yet for this study

Summary

Study Hypotheses:

1. Anaemia, which is frequent before conception as well as during early pregnancy, affects metabolism and foetal growth trajectories, influencing the risk of NCDs in the offspring.
2. Anaemia from conception till end of 2nd trimester is most detrimental for foetal and newborns' health, compared to 3rd trimester anaemia.
3. Anaemia from conception till end of 2nd trimester affects foetal and newborns health through poor placental development reflected in increased villous branching and changed umbilical and uterine blood flow.
4. Anaemia in early pregnancy disrupts the vascular endothelial growth factor A (VEGF-A)/placental growth factor (PlGF) balance and the insulin-like growth factor (IGF) axis resulting in poor placental development, and poor health of newborns. This may be reflected in specific methylation patterns.
5. Anaemia's impact on the risk for NCDs in the offspring may be mediated via epigenetic mechanisms, including changes in DNA methylation patterns.

Conditions

  • Anemia and Pregnancy
  • Metabolism and Foetal Growth
  • Epigenetics

Sponsors & Collaborators

  • Copenhagen University Hospital, Denmark

    collaborator OTHER

  • Aarhus University Hospital

    collaborator OTHER

  • Lund University

    collaborator OTHER

  • National Institute for Medical Research, Tanzania

    collaborator OTHER_GOV

  • Department of Clinical Pathology Naestved Hospital Denmark

    collaborator UNKNOWN

  • University of Copenhagen

    lead OTHER

Principal Investigators

  • Mwelecele N Malecela, PHd · National Institute for Medical Research, Tanzania

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-07-31
Primary Completion
2017-12-31
Completion
2018-10-31

Countries

  • Tanzania

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02191683 on ClinicalTrials.gov