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Neutrophil Extracellular Traps Mediate Antiphospholipid Antibody-induced Pregnancy Loss

NCT03735108 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2018-11-08

No results posted yet for this study

Summary

1. Establish a multi-platform detection system for neutrophil extracellular traps in blood and tissues, and evaluate the detection performance;
2. Comparing the expression levels of neutrophil extracellular traps in peripheral blood and decidua of patients with antiphospholipid antibody-induced pregnancy loss and normal control group;
3. Comparing the expression levels of neutrophil extracellular traps in peripheral blood and decidua of mice with antiphospholipid antibody-induced pregnancy loss and normal control group;
4. After treatment of antiphospholipid antibody-induced mouse abortion model with metformin,the effect of metformin on embryo loss rate and viable embryo body weight was observed.

Conditions

  • Neutrophil Extracellular Traps; Antiphospholipid Antibody-induced Pregnancy Loss

Sponsors & Collaborators

  • Shanghai First Maternity and Infant Hospital

    lead OTHER

Eligibility

Min Age
25 Years
Max Age
41 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-11-01
Primary Completion
2019-06-30
Completion
2019-06-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03735108 on ClinicalTrials.gov