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Dementia and Kidney Disease: Epidemiological Approaches to Risk Factors and Treatment Strategies

NCT07093684 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 200000

Last updated 2025-08-03

No results posted yet for this study

Summary

Kidney disease and dementia are both common in older adults, posing a significant burden on individuals and society. Growing evidence suggests that there may be links between the kidney and the brain. However, few studies have explored how these two conditions are connected in the general population. Understanding this link could help improve care for people living with either or both conditions.

This observational project aims to explore the two-way relationship between kidney disease and dementia. The main questions the investigators want to answer are:

1. Does kidney disease increase the risk or worsen the progression of dementia?
2. Does having dementia increase the risk or worsen the progression of kidney disease (both chronic and acute)?
3. Do reno-protective drugs help protect cognitive decline?
4. Do anti-dementia drugs help preserve kidney function?

To answer these questions, the investigators will analyze data collected over a period of 12 years, including people diagnosed with dementia, kidney disease, or both, using several large Swedish and international health registries:

1. The Swedish Dementia Registry (SveDem)
2. The Stockholm CREAtinine Measurements (SCREAM) project
3. The Swedish Renal Registry (SRR)
4. The GeroCovid Cohort
5. The Registry of Dementia of Girona (ReDeGi)
6. Cognitive impairment cohort from memory clinic, Karolinska University Hospital

This study will apply both traditional and advanced epidemiological methods, including multivariable regression, survival analysis, mixed-effects models, and machine learning (ML) techniques to examine long-term trends and associations.

Conditions

Interventions

OTHER

Kidney disease

This is a registry-based observational study investigating the association between kidney disease and dementia-related outcomes. Kidney disease is not assigned or manipulated by the researchers but is classified as an exposure based on diagnostic codes (e.g., ICD codes), and related laboratory test recorded in health registers.

Sponsors & Collaborators

Principal Investigators

  • Hong Xu · Karolinska Institutet

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-01-01
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Sweden

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07093684 on ClinicalTrials.gov