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Dementia Risk Prediction Model: Development and Validation

NCT03943641 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 400000

Last updated 2024-12-10

No results posted yet for this study

Summary

At present, there is no treatment for dementia that changes the course of the disease. However, it is now understood that the proteins in dementias such as Alzheimer's disease are present years before someone develops symptoms of dementia. Studies may therefore need to give potential treatments to patients before they develop symptoms of dementia. To do this, researchers need a way of predicting who will go on to develop dementia in the future.

There are several ways of doing this, however, many of these methods are costly and difficult to implement at a population level - such as brain imaging, lumbar punctures or psychological tests. In this study, the investigators aim to develop a method of predicting who will go on to develop dementia (and dementia due to Alzheimer's disease) using only the sort of information that a general practitioner would have available to them.

To do this, the investigators will develop a dementia prediction model using data from the Secure Anonymised Information Linkage (SAIL) Databank, which contains anonymised primary care, hospital admissions and mortality data for the population of Wales, United Kingdom (UK). They will then go on to test how well it performs in an external dataset, such as the UK's Clinical Practice Research Datalink (CPRD).

Conditions

  • Dementia Alzheimers

Interventions

OTHER

This is not an intervention study

This study is based on retrospective analysis of linked routinely-collected healthcare data

Sponsors & Collaborators

  • Keele University

    collaborator OTHER

  • University of Edinburgh

    lead OTHER

Eligibility

Min Age
60 Years
Max Age
79 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-05-08
Primary Completion
2024-12-05
Completion
2024-12-05

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03943641 on ClinicalTrials.gov