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The Effect of SSRIs on Threat of Shock Potentiated Neural Circuitry

NCT07074652 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 145

Last updated 2025-07-20

No results posted yet for this study

Summary

This study aims to increase the knowledge about psychological processes which may contribute to mental health problems such as depression and anxiety. This study aims to investigate if administering Escitalopram, an antidepressant which increases serotonin levels in parts of the brain, affects how the brain processes emotional information. It is hoped that measuring these changes will increase the understanding of processes involved in mental health problems.

Conditions

Interventions

DRUG

Escitalopram

Participants received 2-3 weeks of escitalopram.

DRUG

Placebo

Participants received 2-3 weeks of placebo, matched in colour and size to the escitalopram.

Sponsors & Collaborators

  • University College, London

    collaborator OTHER

  • UCLH/UCL Joint Research Office

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-12-01
Primary Completion
2022-06-30
Completion
2022-06-30

Countries

  • United Kingdom

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07074652 on ClinicalTrials.gov