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The Role of Serotonin in Compulsive Behavior in Humans: Underlying Brain Mechanisms

NCT04336228 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 46

Last updated 2024-12-18

No results posted yet for this study

Summary

The aim of this project is to investigate:

* The status of the central serotonin (5-hydroxytryptamine, 5-HT) system in compulsive behaviour and how it is affected by sub-chronic escitalopram administration
* The mechanisms underlying how sub-chronic administration of escitalopram affects the central 5-HT system
* How changes in cognitive performance, including the balance between habitual and goal-directed mechanisms, are affected in compulsive behaviour by boosting 5-HT function
* How functional brain changes in cognitive function measured with magnetic resonance imaging relate to altered 5-HT function following escitalopram administration.

Conditions

  • Obsessive-Compulsive Disorder/High Compulsive Individuals
  • Healthy Individuals

Interventions

DRUG

Escitalopram

20mg daily for 3-4 weeks.

DRUG

Placebo oral tablet

20mg placebo tablet daily for 3-4 weeks.

Sponsors & Collaborators

  • University of Cambridge

    collaborator OTHER

  • Lundbeck Foundation

    collaborator OTHER

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Gitte M. Knudsen, Professor · Neurobiology Research Unit, Rigshospitalet

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-04-01
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • Denmark

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04336228 on ClinicalTrials.gov