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Effort and Antidepressant Study Test

NCT06696482 · Status: NOT_YET_RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2024-11-20

No results posted yet for this study

Summary

The aim of this study is to investigate the behavioural effects and neural correlates of increasing serotonin levels in healthy volunteers, through a 7-day course of the SSRI escitalopram, on an effort-based decision-making task measuring self-benefiting and prosocial behaviours.

Conditions

  • Effort Based Decision Making
  • Prosocial Behavior
  • Apathy

Interventions

DRUG

Escitalopram 10mg

Escitalopram 10 mg, encapsulated in an opaque capsule to facilitate blinding of participant and researcher

DRUG

Placebo 10 mg

Placebo 10 mg, encapsulated in an opaque capsule to facilitate blinding of participant and researcher

Sponsors & Collaborators

  • Wellcome Trust

    collaborator OTHER

  • University of Oxford

    lead OTHER

Principal Investigators

  • Catherine J Harmer, PhD · University of Oxford

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-31
Primary Completion
2025-09-30
Completion
2025-09-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06696482 on ClinicalTrials.gov