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VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility

NCT04089098 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 125

Last updated 2022-06-30

No results posted yet for this study

Summary

This prospective observational study will include critically ill patients with hemodynamic compromise. It will compare passive leg raising and a mini volume challenge (MVC) carried out on every patient sequentially. The endogenous release of stress hormones will also be assayed in order to investigate their modifying effect on the hemodynamic reaction of the participants. The effect of fluid resuscitation on renal perfusion will also be assessed and the data compared with the release of cystatin C.

Conditions

  • Hemodynamic Instability
  • Shock
  • Septic Shock

Interventions

DIAGNOSTIC_TEST

passive leg raising versus mini volume challenge

Blood samples will be collected and ultrasound evaluation of renal perfusion conducted in study participants immediately before conducting passive leg raising (PLR). PLR will then be carried out on study participants, followed by MVC. PLR- and/or MVC-responsive patients will receive a further 700 ml fluid immediately after the MVC. Renal perfusion will be further assessed 1 and 24 hours after the MVC.

Sponsors & Collaborators

  • University of Leipzig

    lead OTHER

Principal Investigators

  • Sirak Petros, MD · University Hospital of Leipzig, Medical ICU

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-09-01
Primary Completion
2021-07-31
Completion
2021-09-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04089098 on ClinicalTrials.gov