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Hyaluronic Acid for Prevention of Post-Intubation Sore Throat and Hoarseness

NCT07040631 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 92

Last updated 2025-06-27

No results posted yet for this study

Summary

The goal of this clinical trial is to find out whether applying Endotra Gel, a hyaluronic acid-based gel, to the endotracheal tube can help reduce sore throat and hoarseness after surgery.

These symptoms are common after general anesthesia when a endotracheal tube is placed into the trachea. They can cause discomfort and affect patient recovery.

The main questions this study aims to answer are:

* Does Endotra Gel reduce the chance of having a sore throat after surgery?
* Does it help improve hoarseness or coughing after surgery?

Participants in this study will:

* Undergo general anesthesia for breast cancer surgery
* Be randomly assigned to one of two groups:

* One group will receive Endotra Gel applied to the endotracheal tube before intubation
* The other group will have standard care with no gel
* Be monitored for sore throat, hoarseness, and coughing right after surgery and on the day after surgery
* Answer questions about their symptoms and satisfaction with their recovery The results will help researchers learn whether using Endotra Gel during intubation can improve patient comfort and reduce airway irritation after surgery.

Conditions

  • Breast Cancer
  • Postoperative Sore Throat, Cough, Hoarseness
  • Endotracheal Intubation
  • General Anesthesia

Interventions

DEVICE

Endotra Gel

Endotra Gel is a hyaluronic acid-based, water-soluble wound dressing gel approved by the Korean Ministry of Food and Drug Safety. In this study, it is applied to the cuff of the endotracheal tube before intubation to evaluate its effect on reducing postoperative sore throat and hoarseness.

Sponsors & Collaborators

  • Pusan National University Yangsan Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
19 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-30
Primary Completion
2026-01-31
Completion
2026-02-28

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07040631 on ClinicalTrials.gov