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Effect of Lidocaine 1% and 2% in the Tube Cuff on Postoperative Sore Throat and Cough

NCT03792776 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2019-01-15

No results posted yet for this study

Summary

Comparing the effect of different methods of endotracheal tube cuff inflation on the occurrence of a postoperative sore throat and cough (Air vs Lidocaine 1% vs Lidocaine 2%).

Conditions

  • Postoperative Sore Throat
  • Postoperative Cough

Interventions

OTHER

cuff inflation with air

Endotracheal tube cuff inflation with air

DRUG

cuff inflation with lidocaine 1%

Endotracheal tube cuff inflation with lidocaine 1%

DRUG

cuff inflation with lidocaine 2%

Endotracheal tube cuff inflation with lidocaine 2%

OTHER

Induction of anesthesia

The induction of anesthesia will be made following a preoxygenation with a facial mask with 100% Oxygen. It consists on the intravenous injection of Sufentanil 5 mcg or Fentanyl 50mcg, Lidocaine 1mg/Kg, Propofol 2.5mg/kg, Rocuronium 0.6mg/kg or Cisatracurium 0.15mg/kg.

OTHER

Maintenance of anesthesia

Maintenance of anesthesia will be done by sevoflurane + nitrous oxide, and reinjections of morphinomimetics and curare will be made as needed (the total doses will be noted at the end of the intervention).

OTHER

Endotracheal intubation

The intubation is made by a N° 7.5 tube in men and a N° 7 tube in women. Cuff inflation will be done upon placement of the endotracheal tube. The cuff's pressure will be monitored at several intervals of the intervention and kept \< or = 20 centimeter of water (cmH2O).

OTHER

Systematic post-operative analgesia

All patients will receive Paracetamol every 6 hours for the first 24 hours after the end of surgery.

Sponsors & Collaborators

  • Ogarite Habib

    lead OTHER

Principal Investigators

  • Hicham Jabbour, MD · Saint JU

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-31
Primary Completion
2019-04-30
Completion
2020-10-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03792776 on ClinicalTrials.gov