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Neuroimaging of Parkinson's

NCT07024875 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2026-04-13

No results posted yet for this study

Summary

Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network (SCAN), which could be a primary locus of dysfunction in PD. Here, the investigators will use magnetic resonance imaging techniques in PD patients to test whether SCAN is critical for PD. The investigators will determine whether SCAN is connected to PD-relevant subcortical structures, and whether PD patients exhibit altered subcortical-to-SCAN connectivity. If successful, this work will identify SCAN as a specific circuit altered in PD patients that can serve as a new target for future neuromodulatory PD therapies.

Conditions

  • Parkinsons Disease (PD)

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    collaborator NIH

  • Michael J. Fox Foundation for Parkinson's Research

    collaborator OTHER

  • Washington University School of Medicine

    lead OTHER

Principal Investigators

  • Evan Gordon, PhD · Washington University School of Medicine

  • Nico Dosenbach, MD/PhD · Washington University School of Medicine

  • Scott Norris, MD · Washington University School of Medicine

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-08-01
Primary Completion
2031-01-31
Completion
2031-01-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07024875 on ClinicalTrials.gov