Serotonin Release in Premotor and Motor PD

Summary

In this study, the investigators aim to provide a deeper understanding of Parkinson's disease and find a biomarker of Parkinson's disease. This is done using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI). The findings will provide a deeper understanding of the brain changes in Parkinson's disease. More importantly, this study will help with the discovery and development of new medications aiming to delay progression of Parkinson's disease symptoms

Conditions

• Parkinson Disease
• Parkinson's
• Parkinson's Disease
• Neurodegenerative Diseases
• Neurodegeneration
• Positron Emission Tomography

Interventions

OTHER

Positron Emission Tomography (PET) scan using CIMBI-36 tracer

This scan creates images of regional serotonin release in by using a tracer compound called CIMBI to highlight the brains capacity to release serotonin.

OTHER

Magnetic Resonance Imaging (MRI) Scan

MRI (magnetic resonance imaging) uses magnets alongside radio waves to create pictures of the brain

OTHER

Positron Emission Tomography (PET) scan using DASB tracer

To create images of the brain using a tracer called DASB, which is a highly selective for serotonin transporters, this highlights serotonin terminals and neurons in the brain.

OTHER

FP-CIT Single-photon Emission Computed Tomography (SPECT) scan

A single-photon emission computerized tomography (SPECT) scan allows analysis of brain function by creating 3D Pictures using compounds called tracers.

OTHER

Lumbar puncture

A lumbar puncture invovles a thin needle is inserted between the bones in your lower spine using local anaesthetic. This allows the collection of Cerebrospinal fluid ( CSF)

Sponsors & Collaborators

• University of Exeter

  lead OTHER

Principal Investigators

• Marios M Politis, Professor · University of Exeter

Eligibility

Min Age

25 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-07-01

Primary Completion

2026-06-30

Completion

2026-06-30

Countries

• United Kingdom

Study Locations