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Cerebral Contributions to Symptom Progression in PD

NCT05169827 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 115

Last updated 2025-02-21

No results posted yet for this study

Summary

Motor symptom progression in early-stage Parkinson's disease varies substantially between individual patients. This progression correlates poorly with striatal dopamine depletion, which is largely complete four years post-diagnosis. Identification of alternative mechanisms, such as cortical compensatory processes, may enable more accurate predictions of individual motor progression.

Conditions

  • Parkinson Disease

Sponsors & Collaborators

  • Radboud University Medical Center

    lead OTHER

Principal Investigators

  • Rick C Helmich, MD, PhD · Donders Centre for Cognitive Neuroimaging

  • Bastiaan R Bloem, MD, PhD · Radboud University Medical Center, Department of Neurology

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-12-01
Primary Completion
2023-11-28
Completion
2023-11-28

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05169827 on ClinicalTrials.gov