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Personalized Hypoxic-hyperoxic Preconditioning in Elderly People

NCT07018895 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-02-09

No results posted yet for this study

Summary

This study investigates an original protocol of personalized hypoxic-hyperoxic preconditioning utilizing a personalized approach on the basis of cerebral tissue oxygenation assessed with near-infrared spectroscopy. 20 healthy elderly volunteers will be randomized into two equal groups. Subjects of the experimental group will undergo personalized sessions of intermittent hypoxic-hyperoxic training (IHHT) based on the cerebral tissue oximetry index assessed with near-infrared spectroscopy with a target reduction of 20%. Subjects of the control group (sham treatment) will undergo placebo procedures with atmospheric air.

Conditions

  • Preconditioning

Interventions

DRUG

Sham treatment

ambient air (FiO2 = 21%) will be delivered for 3 days 1 time a day for 45 minutes

DRUG

FiO2 reduced by 20% alternating with 34% FiO2

FiO2 reduced by 20% alternating with 34% FiO2

Sponsors & Collaborators

  • Tomsk National Research Medical Center of the Russian Academy of Sciences

    lead OTHER

Principal Investigators

  • Nikolay O. Kamenshchikov, MD, PhD · Cardiology Research Institute, Tomsk National Research Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
74 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-07-01
Primary Completion
2025-09-01
Completion
2025-10-03

Countries

  • Russia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07018895 on ClinicalTrials.gov