MedTrace Logo

Investigating the Combined Effects of Intermittent Hypoxia and Exercise on Cognitive and Cerebral Function in Middle-Aged Adults

NCT06874387 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 176

Last updated 2025-03-13

No results posted yet for this study

Summary

This study investigates whether intermittent hypoxia (IH) and physical activity (PA), either alone or in combination (simultaneously or sequentially), can improve cognitive function and brain health in middle-aged adults (50-65 years old). The hypothesis is that (1) each intervention alone (IHT or PA) provides cognitive benefits and (2) combining IHT with PA may yield additive or synergistic effects, particularly when administered simultaneously rather than sequentially. By comparing these distinct interventions, the study aims to determine which approach best preserves or enhances cognitive performance in middle-aged adults. Findings from this research may inform non-pharmacological strategies to promote healthy aging and reduce the risk of age-related cognitive decline.

Conditions

  • Cognitive Ability, General
  • Brain Health
  • Cerebral Oxygenation

Interventions

OTHER

Hypoxia, intermittent

Moderate-Intensity Aerobic Exercise (\~60-70% of maximum heart rate) and Intermittent Hypoxia (maintained between 80-90% during hypoxic phases)

OTHER

physical exercise

Moderate-Intensity Aerobic Exercise (\~60-70% of maximum heart rate)

OTHER

Sham (No Treatment) hypoxia

Exposure to normoxic air (FiO₂ \~20.9%) instead of actual hypoxia.

Sponsors & Collaborators

  • University of Poitiers

    collaborator OTHER

  • Laboratory MOVE, Faculty of Sport Sciences, University of Poitiers, France

    collaborator UNKNOWN

  • Ayoub Boulares

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-04-01
Primary Completion
2026-09-30
Completion
2026-12-30

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06874387 on ClinicalTrials.gov