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Microfluidics Versus Density Gradient Centrifugation for Sperm Preparation in IVF

NCT07004309 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 119

Last updated 2025-06-05

No results posted yet for this study

Summary

This randomized controlled trial aimed to compare the effectiveness of microfluidic sperm sorting and density gradient centrifugation (DGC) in reducing sperm DNA fragmentation index (DFI) and improving clinical outcomes in IVF. A total of 119 couples underwent IVF and were assigned to either microfluidic or DGC sperm preparation. The study evaluated sperm quality, fertilization, embryo development, and live birth rates.

Conditions

  • Male Infertility
  • Sperm DNA Fragmentation
  • In Vitro Fertilization (IVF)

Interventions

PROCEDURE

Microfluidic sperm sorting

Sperm selection using the ZyMot Microfluidic Sperm Separation Device. Process involves loading semen into microfluidic channels to isolate motile sperm with low DNA fragmentation.

PROCEDURE

Density Gradient Centrifugation

Sperm preparation using a discontinuous density gradient technique with SpermGrad and SpermRinse media. Centrifugation separates motile sperm for use in ICSI.

Sponsors & Collaborators

  • Hanoi Medical University

    lead OTHER

Principal Investigators

  • Do Thuy Huong, PhD candidate · Hanoi Medical University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-14
Primary Completion
2024-03-31
Completion
2024-03-31

Countries

  • Vietnam

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07004309 on ClinicalTrials.gov