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Sperm Separation Efficiency to Maximize Pregnancy Rates: MACS vs. FERTILE Chip

NCT04061486 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 84

Last updated 2024-10-04

No results posted yet for this study

Summary

The goal of this observational study is to compare clinical outcomes of two techniques for sperm cell sorting, microfluidic sorting and magnetic activated cell sorting (MACS) technique, in males with high DNA fragmentation within an assisted reproductive treatment. The main questions it aims to answer are:

* Does microfluidic sorting improve pregnancy rate compared to MACS?
* Does microfluidic sorting improve fertilization rate compared to MACS?
* Does microfluidic sorting improve implantation rate compared to MACS?
* Does microfluidic sorting improve blastocyst development rate compared to MACS?

Participants will deposit an eyaculate sample that will be analyzed for DNA fragmentation using a aliquot, then split in two to perform MACS and the microfluidic sorting. Both will be tested for DNA fragmentation (aliquotes) and used for the ICSI treatment with donor oocytes.

Researchers will compare both techniques to see if the selection of the best functional spermatozoa with less DNA fragmentation and clinical outcomes improve.

Conditions

  • Infertility, Male

Sponsors & Collaborators

  • IVI Madrid

    collaborator OTHER

  • Vida Recoletas Sevilla

    lead OTHER

Principal Investigators

  • Cristina González Ravina, PhD · IVI RMA Seville

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-08-08
Primary Completion
2021-05-15
Completion
2022-01-09

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04061486 on ClinicalTrials.gov