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HYEEG Discourse in Psychosis: A Neurobehavioural Study

NCT06978803 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 110

Last updated 2025-05-18

No results posted yet for this study

Summary

This multimodal study explores the mechanisms underlying social dysfunction in individuals with schizophrenia. It focuses on the relationship between disorganized communication and social interaction, aiming to identify measurable markers of disorganized communication and link them to clinical symptoms and social functioning.

Key Research Questions:

How do neural and behavioural synchrony contribute to social impairments in schizophrenia?

What roles do interbrain synchrony, motor imitation, reaction time, and verbal coherence play in disorganized communication?

Participants will:

1. Engage in structured and semi-structured real-time social interactions while undergoing dual-brain electroencephalogram (EEG) hyperscanning to measure neural and behavioural activity.
2. Perform nonverbal tasks such as motor imitation and reaction time assessments to investigate coordination and behavioural synchrony patterns.
3. Participate in a clinical interview that evaluates verbal production, thought coherence, and speech organization.

By combining these assessments, the study aims to advance our understanding of how social and communication impairments manifest in schizophrenia. The findings will contribute to developing improved diagnostic tools and targeted interventions, ultimately supporting patients in achieving better social functioning and quality of life.

Conditions

Sponsors & Collaborators

  • Douglas Mental Health University Institute

    lead OTHER

Principal Investigators

  • Lena Palaniyappan, MD, PhD · Douglas Mental Health University Institute

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-01-16
Primary Completion
2025-10-22
Completion
2026-12-31

Countries

  • Canada

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06978803 on ClinicalTrials.gov