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Comparison of Microbiome Changes in Healthy Adults Following Ketone Ester Consumption

NCT06954675 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-01-26

No results posted yet for this study

Summary

The goal of this observational study is to learn if a ketone ester can improve the content of the gut microbiome. The main questions it aims to answer are:

* Does a ketone ester reduce age-related signatures in the gut microbiome?
* What changes occur in the gut microbiome after consuming a ketone ester?

Participants will:

* Take a ketone ester every day for seven (7) days
* Collect and ship stool samples within seven (7) days before, during, and within seven (7) days after the study period
* Measure their ketone levels with a urine strip every day after having the drink
* Answer questions about their typical diet on a normal day
* Record their symptoms, if any arise

Conditions

  • Microbiome Analysis

Interventions

DIETARY_SUPPLEMENT

Exogenous ketone ester

25g Bis-octanoyl-(R)-1,3-butanediol (C8)

Sponsors & Collaborators

Principal Investigators

  • John C Newman, MD, PhD · University of California, San Francisco

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-11-21
Primary Completion
2026-09-30
Completion
2026-09-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06954675 on ClinicalTrials.gov