Use of a Novel Synbiotic to Change Human Gut Bacteria and Improve Health in Obese Adults

Summary

This study evaluates the effect of a dietary supplement to improve gut health. The participants will take one of six dietary treatments for three weeks, and the gut bacteria and the gut intestinal barrier will be assessed to determine if these dietary treatments beneficially change these markers of gut health.

Conditions

• Intestinal Microbiota and Barrier Function

Interventions

DIETARY_SUPPLEMENT

Bifidobacteria adolescentis BD1

packet containing 10\^9 cells of Bifidobacteria adolescentis BD1

DIETARY_SUPPLEMENT

Bifidobacteria animalis subsp. lactis BB-12

packet containing 10\^9 cells of Bifidobacteria animalis subsp. lactis BB-12

DIETARY_SUPPLEMENT

Bifidobacteria adolescentis BD1 and galactooligosaccharide

packet containing 10\^9 cells Bifidobacteria adolescentis BD1 and 5 g galactooligosaccharide

DIETARY_SUPPLEMENT

Bifidobacteria animalis subsp. lactis BB-12 and galactooligosaccharide

packet containing 10\^9 cells B animalis subsp. lactis BB-12 and 5 g galactooligosaccharide

DIETARY_SUPPLEMENT

galactooligosaccharide

5 g galactooligosaccharide

DIETARY_SUPPLEMENT

Placebo

lactose powder, 5 grams

Sponsors & Collaborators

• University of Nebraska Lincoln

  collaborator OTHER

• University of Alberta

  collaborator OTHER

• Rush University Medical Center

  lead OTHER

Principal Investigators

• Robert Hutkins, PhD · University of Nebraska Lincoln

• Jens Walter, PhD · University of Alberta

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-06-30

Primary Completion

2015-08-31

Completion

2015-10-31

Countries

• United States

Study Locations