Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage

Summary

Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia, brain edema, and hydrocephalus. Complications such as cardiac injury may also arise, categorizing them within the cerebrocardiac syndrome (CCS). The clinical spectrum of CCS encompasses acute myocardial injury, acute coronary syndrome, left ventricular systolic and diastolic dysfunction, cardiac arrhythmias, and sudden cardiac death, all of which are associated with increased mortality and deterioration in patient status. The precise pathophysiological mechanisms underlying both cerebral and cardiac injuries remain enigmatic, and the implications for diagnosis and therapeutic strategies are yet to be fully explored.

In this study, we propose to enroll patients with intracranial hemorrhage who will undergo conventional treatment and comprehensive multidisciplinary evaluations. Our observational research is grounded in a multimodal omics and imaging approach, aimed at investigating both local and systemic injuries subsequent to intracranial hemorrhage. This comprehensive strategy is intended to facilitate precise diagnosis, risk stratification, and clinical decision-making, while also shedding light on the pathophysiological mechanisms involved.

The primary objectives of this research are to address the following key questions:

* \[Question 1\] What are the pathophysiological mechanisms underlying cardiac injury in patients with intracranial hemorrhage?
* \[Question 2\] What are the pathophysiological mechanisms responsible for early and delayed brain injuries following intracranial hemorrhage?\"

Conditions

• Subarachnoid Hemorrhage, Aneurysmal
• Cerebrocardiac Syndrome
• Mass Spectrometry
• Heart Failure
• Atrial Fibrillation
• Ischemic Heart Disease
• Heart Infarction
• Arrhythmias, Cardiac
• Delayed Cerebral Ischemia
• Hydrocephalus
• Vasospasm, Cerebral
• Intracerebral Hemorrhage

Interventions

DIAGNOSTIC_TEST

Multi-disciplinary assessment

Multi-disciplinary assessment including blood tests, CSF test, electrocardiograms, ultrasound, imaging, etc

Sponsors & Collaborators

• Beijing Youyi Hospital

  collaborator UNKNOWN

• Tianjin Medical University General Hospital

  collaborator OTHER

• First Affiliated Hospital of Fujian Medical University

  collaborator OTHER

• Second Affiliated Hospital, School of Medicine, Zhejiang University

  collaborator OTHER

• Gulou Hospital Affiliated to Medical College of Nanjing University

  collaborator UNKNOWN

• Beijing Tiantan Hospital

  lead OTHER

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-08-01

Primary Completion

2034-12-01

Completion

2036-12-01

Countries

• China

Study Locations