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Molecular Mechanisms of Malignant Cerebral Edema After LHI

NCT03703284 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2020-03-03

No results posted yet for this study

Summary

The study is to explore the molecular mechanisms underlying the occurrence of malignant cerebral edema (cerebral hernia) after large hemispheric infarction. Acute LHI (\<=48h) patients that develop cerebral hernia or not within 5 days post-stroke onset, as well as the healthy controls will be studied. The participants will be followed for up to 6 months post stroke-onset, and their modified Rankin Scale (mRS) will be recorded. A mRS score of 0-4 is considered as a favorable outcome while a score of 5-6 as an unfavorable one.

Conditions

  • Cerebral Edema

Interventions

OTHER

Treatments to reduce intracranial pressure

Drugs such as mannitol, glycerin fructose, etc and/or surgery

Sponsors & Collaborators

  • Xuanwu Hospital, Beijing

    lead OTHER

Principal Investigators

  • Yan Zhang, M.D., PhD · Xuanwu Hospital of Capital Medical University

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-01-01
Primary Completion
2022-12-31
Completion
2023-06-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03703284 on ClinicalTrials.gov