MedTrace Logo

Peri-implant Vitamin D and Cathelicidin (LL-37) Levels

NCT06867250 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 33

Last updated 2025-03-10

No results posted yet for this study

Summary

This research aims to explore the influence of vitamin D on the body's defense system by examining its impact on specific proteins involved in immune response and inflammation in the soft tissues surrounding dental implants. Also aims to determine how vitamin D levels affect these proteins and their role in protecting peri-implant tissues from microbial infections and inflammation.

Conditions

  • Peri-Implantitis and Peri-implant Mucositis

Interventions

DIAGNOSTIC_TEST

The patients' periodontal clinical parameters were recorded. PISF samples were collected, and the evaluations of 25(OH)D and LL-37 were conducted using enzyme-linked immunosorbent assay.

In vitro studies have shown that vitamin D promotes the release of antimicrobial peptides from gingival epithelial cells, no clinical research has specifically examined its effect on LL-37 levels in peri-implant tissue diseases. This study seeks to investigate the relationship between vitamin D levels in peri-implant sulcus fluid and clinical parameters in individuals with both peri-implant health and disease. Additionally, it aims to assess the correlation between vitamin D and the antimicrobial peptide LL-37.

Sponsors & Collaborators

  • Altinbas University

    lead OTHER

Principal Investigators

  • ILKNUR OZENCI, Dr · Altinbas University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-04-01
Primary Completion
2021-12-01
Completion
2021-12-01

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06867250 on ClinicalTrials.gov