Low Grade Inflammation in Childhood Obesity : an Independent Risk Factor for Endothelial Dysfunction

Summary

Eligible candidates will be recruited within the children with overweight and obesity having a metabolic risk evaluation before treatment in the period 2006 and 2010 at the pediatric clinic of the UZ Brussel In total 60 participants will be investigated. Firstly, 30 participating patients with initially elevated hsCRP will be selected at random ( following the date of their initial investigation) and afterwards matched for age, BMI z-score, and blood pressure with the same number of patients without initially elevated hCRP values

Data will be collected as follows:

* questionnaires
* clinical examination/ anthropometry
* blood sample (hsCRP)
* peripheral arterial tonometry (endoPAT)

Conditions

• Obesity, Childhood
• Obesity
• Endothelial Dysfunction
• Cardiovascular Risk Factor
• Inflammation

Interventions

DIAGNOSTIC_TEST

Anthropometry

* Actual Height and weight * Calculated BMI from measured weight and height. * Pubertal development (Tanner stage) * Waist circumference * Skin fold measurement (Triceps and Subscapular) * Waist-to-height ratio will be calculated from measured height and waist circumference.

DIAGNOSTIC_TEST

Blood pressure

Blood pressure will be measured using an oscillometric, electronic device (Mindray). The blood pressure will be measured 3 times; the first measurement will not be taken into account and the mean of the second and third measurement will be considered as the real blood pressure.

DIAGNOSTIC_TEST

Peripheral arterial tonometry

The investigator will measure the pulse wave amplitude by using a finger plethysmograph (peripheral arterial tonometry). The investigator will use the EndoPAT device from Itamar Medical Ltd. At the end of the examination, the participants will be asked to give a VAS-score (Visual Analogue Pain scale).

OTHER

Questionnaire

General questionnaire on cardiovascular risk factors

DIAGNOSTIC_TEST

Blood sample

Blood sample for hs-CRP

Sponsors & Collaborators

• Universitair Ziekenhuis Brussel

  lead OTHER

Principal Investigators

• Jean De Schepper, PhD · Universitair Ziekenhuis Brussel

• Inge Gies, PhD · Universitair Ziekenhuis Brussel

Study Design

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

12 Years

Max Age

21 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-03-01

Primary Completion

2021-12-31

Completion

2021-12-31

Countries

• Belgium

Study Locations