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Genetics of Fatty Liver Disease in Children

NCT01966627 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 381

Last updated 2017-12-08

No results posted yet for this study

Summary

This is a study to investigate genetic predisposition to hepatic steatosis and the expression of gluconeogenic and lipogenic genes in livers of obese children and adolescents.

Hypothesis 1: Common variants recently associated with variation in plasma TG levels identified in Genome Wide Association Studies (GWAS) (such as GCKR, PNPLA3) can affect accumulation of fat and subsequent development of Non Alcoholic Fatty Liver Disease (NAFLD). Gene variants act in additive or synergistic manner with progressive liver fat accumulation per additional risk allele.

Hypothesis 2: With increase in hepatic fat content NASH and fibrosis will increase. Furthermore, expression of lipogenic markers (SREBP1c) will increase.

Conditions

  • Non Alcoholic Fatty Liver Disease

Interventions

OTHER

ogtt

oral glucose tolerance test

OTHER

genotyping

genotyping to look for risk alleles

OTHER

abdominal and liver magnetic resonance imaging

magnetic resonance imaging scan of abdomen and liver - abdominal and liver mri

OTHER

stool sample

stool sample taken to investigate metabolites

OTHER

liver biopsy

liver biopsy to examine for cellular change and steatosis

Sponsors & Collaborators

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

    collaborator NIH

  • Yale University

    lead OTHER

Principal Investigators

  • Sonia Caprio, M.D. · Yale University

Eligibility

Min Age
7 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-07-31
Primary Completion
2017-07-31
Completion
2017-07-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01966627 on ClinicalTrials.gov