MedTrace Logo

Biomarkers for Cognitive Decline in Intracerebral Hemorrhage

NCT06836141 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 118

Last updated 2025-08-08

No results posted yet for this study

Summary

The goal of this clinical trial is to see if silent brain infarcts (SBIs), or stroke-like symptoms detectable during brain imaging, are a possible contributor to cognitive decline for patients diagnosed with spontaneous intracerebral hemorrhage (sICH), or blood clot in the brain. The main questions it aims to answer are

* if SBIs in sICH are associated with a lower cognitive level and more rapid cognitive decline
* if SBIs in sICH are associated with certain findings on brain imaging
* if SBIs in sICH are associated with higher inflammation measured by certain blood tests

Participants will undergo

* cognitive testing during hospitalization, and at 3, 6 and 12 months after the sICH
* Magnetic Resonance Imaging (MRI) of the brain during hospitalization and 12 months after the sICH
* blood draws during hospitalization and at 3, 6 and 12 months after the sICH

Conditions

  • Primary Intracerebral Hemorrhage

Interventions

DIAGNOSTIC_TEST

MRI

MRI during hospitalization and at 12 months post sICH

DIAGNOSTIC_TEST

Blood Draw

Will occur during hospitalization and at 3, 6 and 12 months post sICH

DIAGNOSTIC_TEST

Cognitive Test

Cognitive testing will occur during hospitalization and at 3, 6 and 12 months post sICH

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    collaborator NIH

  • Rush University Medical Center

    lead OTHER

Principal Investigators

  • Rajeev Garg, MD · Rush University Medical Center

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-02
Primary Completion
2029-08-01
Completion
2029-08-01

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06836141 on ClinicalTrials.gov