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Neuroimaging Correlates of Memory Decline Following Carotid Interventions

NCT02006095 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 207

Last updated 2022-08-29

No results posted yet for this study

Summary

Carotid revascularization can significantly reduce the risk of stroke in patients with severe carotid stenosis; however, it has been associated with cognitive decline in 25% of the older adults who undergo the procedure. Characterizing risk factors for cognitive decline following carotid interventions and individualizing treatment strategy based on those risks can minimize procedure-associated cognitive dysfunction. Neuroimaging techniques that characterize white matter integrity and regional hypoperfusion have the potential to provide sensitive brain structure indicators that may be associated with memory decline following revascularization procedures. In this protocol, we hope to determine how cerebral blood flow and baseline white matter abnormality in the vulnerable region modify the frequency and cognitive effect of microembolization following carotid revascularization procedures.

Conditions

  • Carotid Artery Stenosis

Interventions

OTHER

Magnetic resonance imaging

arterial spin labeling, diffusion tensor imaging, and diffusion weighted imaging sequences will be used

BEHAVIORAL

Neuropsychological testing

Sponsors & Collaborators

Principal Investigators

  • Wei Zhou, MD · Palo Alto Veterans Affairs/Stanford University

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-11-30
Primary Completion
2018-04-30
Completion
2018-04-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02006095 on ClinicalTrials.gov