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Predictors of Relapse in Major Depressive Disorder (PERFORM-D)

NCT06746155 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 252

Last updated 2026-05-22

No results posted yet for this study

Summary

Major depressive disorder (MDD) is a common condition involving recurring periods of depression. One of the major challenges faced by people with MDD is that the episodes of depression tend to recur even after they are successfully treated. Currently, it is hard to predict when a depressive episode will recur. Being able to forecast this would help healthcare providers monitor patients and prevent relapse.

The purpose of this study is to monitor features such as clinical symptoms, physical activity, sleep patterns, cognitive functioning and brain activity to help us understand how relapse happens and the mechanisms that cause it. From these different types of data, investigators will build a model that tells us who is more likely to experience a relapse and when the relapse is likely to occur.

This study will be a significant step forward in understanding and managing MDD. Investigator will create a practical tool that will allow healthcare providers to monitor patients more effectively. By identifying early signs of relapse, investigators may be able to intervene promptly to prevent depressive episodes. Finally, our research will help understand the factors that underlie relapse in MDD, which will encourage the development of novel treatment approaches.

Conditions

  • Major Depressive Disorder (MDD)

Sponsors & Collaborators

  • McMaster University

    collaborator OTHER

  • University of British Columbia

    collaborator OTHER

  • University of Calgary

    collaborator OTHER

  • Ontario Shores Centre for Mental Health Sciences

    collaborator OTHER

  • Queen's University

    collaborator OTHER

  • Nova Scotia Health Authority

    collaborator OTHER

  • University Health Network, Toronto

    collaborator OTHER

  • Centre for Addiction and Mental Health

    collaborator OTHER

  • Abraham Nunes

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-27
Primary Completion
2028-10-01
Completion
2029-10-01

Countries

  • Canada

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06746155 on ClinicalTrials.gov