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Precision Medicine in the Depression Treatment

NCT05616559 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 800

Last updated 2024-10-08

No results posted yet for this study

Summary

The BrainDrugs-D study uses multimodal neuroimaging combined with self-report measures, clinical and molecular markers to identify clinically relevant predictors that can identify subtypes of major depressive disorder (MDD) and, in a naturalistic setting, predict treatment response to standard antidepressive treatment. The cohorts are followed in nationwide health registries.

Conditions

  • Depressive Disorder, Major
  • Treatment Outcome
  • Cognitive Dysfunction
  • Cognitive Behavioral Therapy
  • Antidepressive Agents

Interventions

COMBINATION_PRODUCT

Treatment Package for First-Episode Depression

The outpatient 'treatment package' for first episode depression is a national uniform package designed by Mental Health Services in the Capital Region. The treatment package for first-episode depression is a program with manualized group CBT, psychoeducation of patients and relatives, and relapse prevention. Antidepressant medication and individual psychotherapy are available as needed.

Sponsors & Collaborators

  • Mental Health Services in the Capital Region, Denmark

    collaborator OTHER

  • Center for Integrated Molecular Brain Imaging, Copenhagen, Denmak

    collaborator OTHER

  • Lundbeck Foundation

    collaborator OTHER

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Martin B Jørgensen, DMSc · Psychiatric Center Copenhagen

  • Gitte MK Knudsen, DMSc · Neurobiology Research Unit, Rigshospitalet

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-15
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05616559 on ClinicalTrials.gov