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Sedentary or Exercised : Neuromuscular and Immunometabolic Observations and Retrospection

NCT06692543 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-05-22

No results posted yet for this study

Summary

The distinction between healthy and pathological ageing has given rise to the vitality capacity concept. Underlying the physiological aspect of ageing, vitality capacity is reflected in the neuromuscular function, metabolism, and immune and stress response. The three domains seem to deteriorate with age, except among individuals who have maintained physical activity throughout their lives. Furthermore, immune cells, particularly T lymphocytes, appear to play a key role in each dimension of vitality capacity, as well as in the mice ageing pathway. Investigators sought to determine the effect of lifelong physical activity on vitality capacity, and especially on T cell metabolism.

In this optic, fourty healthy participants over the age of 55 will be allocated to two groups: 20 who have maintained physical activity for the past 30 years, and 20 who have not. Each participant's vitality capacity will be deeply tested and compared to their physical activity background.

Conditions

  • Aging

Interventions

OTHER

Active population

1 blood withdraw, questionnaire and tests

OTHER

Inactive population

1 blood withdraw, questionnaire and tests

Sponsors & Collaborators

  • LAMHESS

    collaborator UNKNOWN

  • Institut de bilogie de Valrose

    collaborator UNKNOWN

  • INSERM-C3M

    collaborator UNKNOWN

  • LP2M

    collaborator UNKNOWN

  • Centre Hospitalier Universitaire de Nice

    lead OTHER

Principal Investigators

  • Olivier GUERIN, MD · Centre Hospitalier Universitaire de Nice

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-04-14
Primary Completion
2028-04-30
Completion
2028-12-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06692543 on ClinicalTrials.gov