Physical Activity as Intervention Against Age-related Loss of Muscle Mass and Function

Summary

A minimum of 450 healthy individuals (62-70 years old) will be recruited.

Each individual will be randomized into one of three groups stratified according to gender (M/F), BMI (≤28/\>28), and 30 sec chair stand (≤11/\>11). The three groups are Heavy resistance training (n=150), moderate intensity training (n=150), and control (n=150, no training).

Assessments will be performed at baseline, after 12 months of intervention. Furthermore, follow up will be performed after 2,4,7, and 10 years.

The primary outcome is change in leg extensor power after the intervention and during follow up.

The primary hypothesis is that by applying the intention-to-treat analysis, the moderate intensity training group will increase leg extensor power just as much as the heavy resistance training group. The two training groups will increase muscle power more than the control group.

Conditions

• Muscle Weakness
• Muscle Loss
• Sarcopenia
• Physical Activity

Interventions

OTHER

Heavy resistance training

Supervised heavy resistance training three times weekly for 52 weeks.

OTHER

Moderate intensity training

Moderate intensity training supervised once weekly and home based unsupervised two times weekly for 52 weeks.

OTHER

Control

No training

Sponsors & Collaborators

• University of Copenhagen

  collaborator OTHER

• Hvidovre University Hospital

  collaborator OTHER

• Bispebjerg Hospital

  lead OTHER

Principal Investigators

• Kasper Dideriksen, PhD stud · Bispebjerg Hospital

• Anne Gylling, PhD stud · Bispebjerg Hospital

• Christian Eriksen, PhD stud · Bispebjerg Hospital

• Michael Kjaer, MD, Proff · Bispebjerg Hospital

• Andreas Ziegler, PhD stud · Bispebjerg Hospital

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

62 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2014-04-30

Primary Completion

2028-06-30

Completion

2028-06-30

Countries

• Denmark