MedTrace Logo

Does Co-administration of Lactate Affect Postprandial Nutrient Absorption and Fat Disposition?

NCT06668714 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2025-06-19

No results posted yet for this study

Summary

Aim To investigate the effects of oral lactate administration on nutrient absorption and substrate utilization in individuals with pre-diabetes.

Hypothesis The addition of lactate to a meal improves postprandial lipemia and reduces lipid storage in ectopic tissues through delayed absorption and faster removal of circulating lipids from circulation.

Conditions

  • Pre Diabetes
  • Metabolic Syndrome

Interventions

COMBINATION_PRODUCT

Placebo + mixed meal

Placebo (140 mL isoosmotic salt water, NaCl) given 30 minutes before a liquid test meal with the addition of 70 MBq 18F-FTHA = CTR

COMBINATION_PRODUCT

Lactate + mixed meal

Lactate (140 mL lactate drink = 25 g D/L-lactate bound to Na) given 30 minutes before a liquid test meal with the addition of 70 MBq 18F-FTHA = LAC The investigators will also use the 18F-FTHA standardized uptake value (SUV) to evaluate dietary fatty acid trapping and distribution, to be able to compare our results with former studies using the 18F-FTHA method.

RADIATION

PET-scan

Dynamic whole-body PET scan.

COMBINATION_PRODUCT

Mixed meal with 18F-FTHA

Mixed meal test with the addition of 70 MBq 18F-FTHA

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Esben Søndergaard · Aarhus University, Steno Diabetes Center Aarhus

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-08-22
Primary Completion
2026-01-31
Completion
2026-01-31

Countries

  • Denmark

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06668714 on ClinicalTrials.gov