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Bone Properties Following Exercise Induced Changes in Insulin Sensitivity in People With Type 2 Diabetes

NCT06668090 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2025-08-14

No results posted yet for this study

Summary

Diabetes mellitus type 2 is associated with low bone turnover and increased risk of bone fractures.

Bone mineral density, however, is increased and cannot explain the increased fracture risk per se. The pathophysiology is not completely understood, but the decrease in bone turnover is believed to cause an accumulation of microcracks in bone tissue leading to bone fragility. The decrease in bone turnover may arise directly from insulin resistance or indirectly through formation of advanced glycation end-products.

The main aim objective is to investigate how increases in insulin sensitivity following 12 weeks of moderate intensity bike exercise affect biochemical bone turnover markers and biomechanical bone properties in individuals with diabetes mellitus type 2.

Conditions

  • Diabetes Mellitus, Type 2
  • Insulin Resistance
  • Bone Diseases, Metabolic
  • Osteoporosis, Osteopenia
  • Musculoskeletal Diseases
  • Metabolic Disease
  • Glucose Metabolism Disorders

Interventions

BEHAVIORAL

Moderate intensity bike exercise

Participants will do moderate intensity bike exercise for up to one hour thrice weekly for 12 weeks.

Sponsors & Collaborators

  • The Novo Nordic Foundation

    collaborator OTHER

  • Aalborg University Hospital

    collaborator OTHER

  • Aarhus University Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-12-15
Primary Completion
2025-06-26
Completion
2025-06-28

Countries

  • Denmark

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06668090 on ClinicalTrials.gov