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Prevalence of Vertebral Fractures in Patients With Type 1 Diabetes

NCT04064437 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 192

Last updated 2024-02-13

No results posted yet for this study

Summary

Background : Type 1 diabetes is associated with an increased risk of fractures. The mechanisms accounting for this bone fragility are not yet fully understood. The lower bone mineral density (BMD) observed in individuals with type 1 diabetes cannot solely explain the higher fracture incidence. Bone microarchitecture defects significantly contribute to bone fragility. Few studies assessed spine fractures in type 1 diabetes.

This cross-sectional multicenter case-control study aims (1) to evaluate the prevalence of asymptomatic vertebral fractures in individuals with type 1 diabetes in comparison to age- and sex-matched healthy controls; (2) to compare individuals with diabetes with vertebral fractures and those without vertebral fracture using clinical, biochemical and radiological parameters.

Conditions

  • Diabetes Mellitus, Type 1
  • Bone Fracture
  • Bone Health

Interventions

DIAGNOSTIC_TEST

Clinical tests

The investigators perform the following clinical tests: vibration threshold test, monofilament test, and height, weight and waist circumference measurement in every participant.

DIAGNOSTIC_TEST

Clinical tests

The investigators perform the following clinical tests: height, weight and waist circumference measurement in every participant.

DIAGNOSTIC_TEST

Biochemical tests

The investigators perform blood and urine tests in every participant.

DIAGNOSTIC_TEST

DXA scan

The investigators perform a dual energy x-ray absorptiometry (DXA scan or osteodensitometry) in every participant.

DIAGNOSTIC_TEST

AGE Reader

The investigators perform a skin advanced glycation end products (AGEs) measurement with the AGE Reader machine in every participant.

Sponsors & Collaborators

  • CHU de Quebec-Universite Laval

    lead OTHER

Principal Investigators

  • Claudia Gagnon, Dr · CHU de Québec - Université Laval

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-07-29
Primary Completion
2021-03-02
Completion
2021-03-02

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04064437 on ClinicalTrials.gov