Preventing Diabetic Osteoporosis With Exercise

Summary

The two specific aims of the study were to determine whether:

1. Greater mechanical loading of downhill exercise will increase the osteogenic index (ratio between CICP, the marker of bone formation (c-terminal propeptide of type I collagen, and CTX, the marker of bone resorption (c terminal telopeptide of type I collagen)) to a greater extent than uphill exercise that provides lower ground-reaction force;
2. Exercise after the meals will induce greater osteogenic response than exercise pefore the meals as it is known that meal eating during daytime inhibits bvone resorption markers.

Conditions

• Diabetes Mellitus, Type 2

Interventions

COMBINATION_PRODUCT

Behavior intervention of uphill exercise

40 minutes of uphill exercise

COMBINATION_PRODUCT

Dietary intervention of exercise before the meal

40 minutes of uphill exercise completed 1 h before the meal

COMBINATION_PRODUCT

Dietary intervention of uphill exercise

40 minutes of uphill exercise

COMBINATION_PRODUCT

Dietary intervention of exercise after the meal

40 minutes of uphill exercise started 1 hour after gthe meal

COMBINATION_PRODUCT

Behavior intervention of downhill exercise

40 minutes of downhill exercise

COMBINATION_PRODUCT

Dietary intervention of exercise before the meal

40 minutes of downhill exercise completed 1 hour before the meal

COMBINATION_PRODUCT

Behavioral intervention of downhill exercise

40 minutes of downhill exercise

COMBINATION_PRODUCT

Dietary intervention of exercise after the meal

40 minutes of downhill exercise started 1 hour after the meal

COMBINATION_PRODUCT

Behavioral intervention of sedentary no-exercise trial

Sedentary no-exercise trial

COMBINATION_PRODUCT

Dietary intervention of eating two meals

Meals eaten at 10 and 17 h during a sedentary trial

Sponsors & Collaborators

• University of Wisconsin, La Crosse

  collaborator OTHER

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  collaborator NIH

• University of Michigan

  lead OTHER

Principal Investigators

• Katarina T Borer · Professor Emerita

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

FACTORIAL

Eligibility

Min Age

50 Years

Max Age

65 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2009-10-08

Primary Completion

2012-12-05

Completion

2012-12-20