MedTrace Logo

Human Papillomavirus Association and Genomic Exploration in Head-Neck Squamous Cell Carcinomas

NCT06642324 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 550

Last updated 2024-12-31

No results posted yet for this study

Summary

Head and neck squamous cell carcinoma (HNSCC) represents a significant public health burden in Bangladesh with a high incidence and mortality rate. While traditional risk factors like tobacco and betel nut chewing contribute to HNSCC incidence, the emergence of HPV-associated HNSCC presents a unique challenge. The main goal of this observational study is to explore the prevalence, risk factors, and biological mechanisms underlying food habits and HPV-driven HNSCC in the population and identify the genomic changes and characteristics related to this malignancy. This study will provide the prevalence of HPV-associated HNSCC and screening the HPV typing in the Bangladeshi population, identify risk factors, and any biologically driven mechanisms causing HNSCC.

Conditions

  • Head Neck Cancer
  • Oropharyngeal Neoplasms

Interventions

DIAGNOSTIC_TEST

Histopathology, Immunohistochemistry, Real-Time PCR, Sequencing

Histopathology for carcinoma detection, Immunohistochemistry for carcinoma-related protein expression, Real-Time PCR for HPV association and HPV typing, Sequencing for genetic study or mutation analysis.

Sponsors & Collaborators

  • Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

    lead OTHER

Principal Investigators

  • S M Rashed Ul Islam, M. Phil, MPH · Bangabandhu Sheikh Mujib Medical University (BSMMU)

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-04-30
Primary Completion
2025-03-30
Completion
2025-09-30
FDA Device
Yes

Countries

  • Bangladesh

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06642324 on ClinicalTrials.gov