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Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas

NCT06236464 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 170

Last updated 2025-07-29

No results posted yet for this study

Summary

This is a multicentric, retrospective, and prospective biomarker study.

Conditions

  • Squamous Cell Carcinoma of the Head and Neck
  • Squamous Cell Carcinoma of the Anus

Interventions

OTHER

Multiparameter analysis of each sample

Retrospective and prospective samples will be collected and analyzed for the study of molecular and viral biomarkers. Simultaneously, fibroblastic tumor-associated cells (CAFs) will be isolated from prospective samples. Through co-cultivation with immortalized cell lines derived from anogenital and head-neck SCCs, these CAFs will enable the production of 3D organoids for use in experiments assessing the response to telomerase and deacetylase SIRT1 inhibitors, both in vitro and in preclinical models.

Sponsors & Collaborators

  • National Cancer Institute, Naples

    lead OTHER

Principal Investigators

  • Maria Lina Tornesello, M.D. · IRCCS I.N.T. "G. Pascale"

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-25
Primary Completion
2025-11-19
Completion
2026-03-31

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06236464 on ClinicalTrials.gov