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Efficacy of a Water Intervention in Institutionalized Aged Population.

NCT06497426 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 17

Last updated 2026-03-27

No results posted yet for this study

Summary

Background: As a person ages, there is a decrease in the body's ability to respond to feeding and exercise anabolic stimuli and to produce muscle proteins. Causes of this anabolic resistance in aged population are not well known. Total body water also decreases with age and has been related with muscle mass, strength and performance.

Objective: The aim of this study is to assess the effect of a water intervention on anabolic resistance and on some physiological adaptive response to water loss indicators in institutionalized aged population. Methodology: Design and population: randomized controlled trial with two parallel arms in ≥65-year-old institutionalized subjects. Study intervention: supervised water ingestion (30-35 ml/kg/day) during 7 consecutive days. Control intervention: usual care (water ingestion ad libitum). Main outcome measures: a)anabolic resistance (nitrogen balance, 3-methyl-histindine, urea excretion, plasmatic and urinary urea and urea/high index), b) indicators of physiological adaptive mechanism to water conservation (copeptin, sympathetic tone, inflammatory indicators, anabalic and catabolic hormones), c)muscle mass (according to bioimpedance analysis), grip strength (JAMAR dynamometer), sarcopenia (according to EWGSOP 2 criteria), and d) clinical recovery.

Controls and follow-up: at 1 week and hospital discharge.

Conditions

  • Muscle Loss

Interventions

OTHER

Study intervention

Participants will be asked to drink water. Water intake will be supervised by a nurse/nurse assistant/dietitian team to ensure adherence, and registered to assess intervention compliance.

Sponsors & Collaborators

  • Consorci Sanitari del Maresme

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-06-15
Primary Completion
2025-05-15
Completion
2025-06-15

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06497426 on ClinicalTrials.gov