Impact of Acute Hospitalisation and Resistance Training on Muscle Architecture and Physical Performance in Older Adults

Summary

Sarcopenia characterised by loss of muscle mass, muscle strength and physical performance burdens many older adults since the condition is related to functional decline. Periods of inactivity such as during hospitalisation leads to further functional decline. It has been reported that the loss of muscle mass associated with sarcopenia not only entails a decrease in muscle mass but also changes in muscle architecture. Knowledge on changes in muscle architecture is essential since it is one of the most important determinants on muscle strength and thus physical performance. The main objective of this study is to investigate changes in muscle architecture and physical performance during acute hospitalisation and after discharge in older adults and subsequently the effectiveness of resistance training of the lower limb during acute hospitalisation. If successful, our study could have a great impact on the individual, as well as societal level, due to a better understanding of the factors related to sarcopenia and the prevention of functional decline as a result of hospitalisation.

Conditions

• Sarcopenia
• Functional Decline
• Muscle Architecture
• Gait Speed
• Ultrasound
• Physical Performance
• Resistance Training
• Hospitalisation
• Acutely Ill
• Older Adults

Interventions

OTHER

Resistance training

Moderate resistance training by a innovative training robot 2 times a day during hospitalisation

Sponsors & Collaborators

• University of Copenhagen

  collaborator OTHER

• Nottingham University Hospitals NHS Trust

  collaborator OTHER

• Odense University Hospital

  lead OTHER

Principal Investigators

• Kristian B Buhl, MD · Department of Geriatric, Odense University Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-01-05

Primary Completion

2024-12-20

Completion

2024-12-20

Countries

• Denmark

Study Locations